Research into safety of in vitro methods to mature gametes
FOBI aims to discover potentially harmful influences in oocyte culture that might lead to defects in the normal imprinting processes.
Donated human oocytes from healthy volunteers and consenting patients, and oocytes cultured with several in-vitro maturation systems for immature oocytes are used as sources for hypothesis testing. As species might have a different susceptibility towards external influences, back-to-back experiments are performed in a mouse model and in human.
The developed assays can be used for testing epigenetic safety of culture media and drugs and for assessment of potential harmful effects of metabolic disturbances and xenobiotic substances.